Tissue-engineered vascular grafts for congenital cardiac disease: Clinical experience and current status.

Abstract

Congenital heart disease is a leading cause of death in the newborn period, and man-made grafts currently used for reconstruction are associated with multiple complications. Tissue engineering can provide an alternative source of vascular tissue in congenital cardiac surgery. Clinical trials have been successful overall, but the most frequent complication is graft stenosis. Recent studies in animal models have indicated the important role of the recipient׳s immune response in neotissue formation, and that modulating the immune response can reduce the incidence of stenosis.

• Authors: Joseph D Drews, Hideki Miyachi, Toshiharu Shinoka
• Journal: Trends in cardiovascular medicine (Trends Cardiovasc Med) Vol. 27 Issue 8 Pg. 521-531 (11 2017) ISSN: 1873-2615 [Electronic] United States
• PMID: 28754230 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Topics

• Adolescent
• Adult
• Animals
• Bioprosthesis
• Blood Vessel Prosthesis
• Blood Vessel Prosthesis Implantation (adverse effects, instrumentation)
• Cell Transplantation (adverse effects, methods)
• Child
• Child, Preschool
• Female
• Graft Occlusion, Vascular (etiology, immunology, physiopathology)
• Heart Defects, Congenital (pathology, physiopathology, surgery)
• Humans
• Infant
• Male
• Patient Selection
• Prosthesis Design
• Risk Factors
• Tissue Engineering (methods)
• Tissue Scaffolds
• Treatment Outcome
• Vascular Patency
• Young Adult