The association of isoconazole-diflucortolone in the treatment of pediatric tinea corporis.

Abstract

BACKGROUND:

Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching.

OBJECTIVE:

From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus.

METHODS:

In 2012, we decided to treat all children with a single lesion of tinea corporis with a combination of 1% isoconazole nitrate and 0.1% diflucortolone valerate cream (one application/day for 5-7 days), followed by a treatment with isoconazole or clotrimazole or ciclopirox cream (two applications/day for two weeks).

RESULTS:

From 2012 to 2014, we observed 108 children with tinea corporis confirmed by mycological examinations. Clinical and mycological recovery was observed in 93 of them (86.1%). Only four of these children (3.7%) developed S. aureus superinfections.

CONCLUSIONS:

Our study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association isoconazole-diflucortolone is useful and safe.

• Authors: Stefano Veraldi, Rossana Schianchi, Paolo Pontini, Alberto Gorani
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 29 Issue 2 Pg. 200-201 (Mar 2018) ISSN: 1471-1753 [Electronic] England
• PMID: 28753055 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Ointments
• Miconazole
• isoconazole
• Diflucortolone

Topics

• Administration, Topical
• Antifungal Agents (therapeutic use)
• Child
• Child, Preschool
• Dermatitis, Atopic (complications)
• Diflucortolone (chemistry, therapeutic use)
• Drug Administration Schedule
• Female
• Humans
• Male
• Miconazole (analogs & derivatives, chemistry, therapeutic use)
• Ointments (chemistry, therapeutic use)
• Staphylococcus aureus (isolation & purification)
• Superinfection (diagnosis, drug therapy, microbiology)
• Tinea (drug therapy)
• Treatment Outcome