Postoperative local-regional radiation therapy in the treatment of parathyroid carcinoma: The MD Anderson experience of 35 years.

Abstract

PURPOSE:

We aimed to investigate outcomes of locoregional radiation therapy (XRT) in parathyroid carcinoma (PC) patients at a single institution over 35 years.

METHODS AND MATERIALS:

Retrospective review of PC patients who received postoperative locoregional XRT (1980-2015). Patients were grouped according to XRT after PC initial operation or after salvage surgery. All patients with a histopathological diagnosis of PC who had postoperative locoregional XRT at our institution were included. All patients with a histopathological diagnosis of uncertain malignancy, suggestive for malignancy, or atypical parathyroid tumors and those who had XRT outside our institution were excluded.

RESULTS:

Eight patients received XRT, 4 in each group, with a median follow-up of 12.5 years. The 4 patients who had XRT after initial surgery all had an oncologic operation, including ipsilateral thyroid lobectomy and central neck dissection, and all of these patients were disease-free at last follow-up. Of the 4 patients who received XRT after salvage surgery, only 1 remained disease free. There were no major complications/long-term side effects associated with XRT.

CONCLUSIONS:

XRT is well tolerated as postoperative locoregional treatment of patients with PC. Whether it is needed, and the timing of administering XRT, remains to be established.

• Authors: Ioannis Christakis, Angelica M Silva, Michelle D Williams, Adam Garden, Elizabeth G Grubbs, Naifa L Busaidy, Jeffrey E Lee, Nancy D Perrier, Mark Zafereo
• Journal: Practical radiation oncology (Pract Radiat Oncol) 2017 Nov - Dec Vol. 7 Issue 6 Pg. e463-e470 ISSN: 1879-8519 [Electronic] United States
• PMID: 28751227 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (pathology, radiotherapy)
• Parathyroid Neoplasms (complications, pathology, radiotherapy, surgery)
• Parathyroidectomy
• Radiotherapy (adverse effects)
• Radiotherapy Planning, Computer-Assisted
• Retrospective Studies
• Salvage Therapy
• Treatment Outcome