Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis.

Abstract	Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.
Authors	Andrzej T Slominski, Anna A Brożyna, Robert C Tuckey
Journal	The Journal of investigative dermatology (J Invest Dermatol) Vol. 137 Issue 8 Pg. 1609-1611 (08 2017) ISSN: 1523-1747 [Electronic] United States
PMID	28735612 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural, Comment)
Copyright	Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Chemical References	Anti-Inflammatory Agents Receptors, Glucocorticoid Hydrocortisone
Topics	Administration, Cutaneous Anti-Inflammatory Agents (administration & dosage, pharmacokinetics) Humans Hydrocortisone (administration & dosage, pharmacokinetics) Psoriasis (drug therapy, metabolism, pathology) Receptors, Glucocorticoid (metabolism) Signal Transduction Skin (drug effects, metabolism, pathology)

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