Redox imbalance in a model of rat mimicking Hutchinson-Gilford progeria syndrome.

Abstract

Although several etiological factors contribute to the complexity of the aging process, the ultimate component of macromolecular damage and consequent cell death involves the altered redox balance inclined towards increased ROS production and/or decreased antioxidant protection. Given that, the chronic dihydrotachysterol (DHT) intoxication in rats induce Hutchinson Gilford progeria like syndrome, the present study provides the evidence for altered redox balance as evidenced by alteration in parameters of oxidative stress in blood plasma and erythrocytes including MDA, GSH, FRAP AOPP PMRS, AGEs, AChE and osmotic fragility which substantiate the suitability of the model for aging studies.

• Authors: Manoj Kumar Chaudhary, Sandeep Singh, Syed Ibrahim Rizvi
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 491 Issue 2 Pg. 361-367 (09 16 2017) ISSN: 1090-2104 [Electronic] United States
• PMID: 28728841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Advanced Oxidation Protein Products
• Antioxidants
• GPI-Linked Proteins
• Reactive Oxygen Species
• Malondialdehyde
• ACHE protein, human
• Acetylcholinesterase
• Glutathione
• Dihydrotachysterol

Topics

• Acetylcholinesterase (blood)
• Advanced Oxidation Protein Products (blood)
• Aging (drug effects, metabolism, pathology)
• Animals
• Antioxidants (metabolism)
• Dihydrotachysterol
• Disease Models, Animal
• Erythrocytes (drug effects, metabolism)
• Female
• GPI-Linked Proteins (blood)
• Glutathione (blood)
• Humans
• Malondialdehyde (blood)
• Oxidation-Reduction (drug effects)
• Oxidative Stress
• Progeria (blood, chemically induced, pathology)
• Rats
• Rats, Wistar
• Reactive Oxygen Species (blood)