Abstract | BACKGROUND: METHODS AND RESULTS: We evaluated 69 426 new users of ACE-I/ARB therapy in the Stockholm Creatinine Measurements (SCREAM) project with medication initiation from January 1, 2007 to December 31, 2010, and follow-up for 1 year thereafter. Three fourths (76%) of SCREAM patients had potassium checked within the first year. Potassium >5 and >5.5 mmol/L occurred in 5.6% and 1.7%, respectively. As a comparison, we propensity-matched new ACE-I/ARB users to 20 186 new β-blocker users in SCREAM: 64% had potassium checked. The occurrence of elevated potassium levels was similar between new β-blocker and ACE-I/ARB users without kidney disease; only at estimated glomerular filtration rate <60 mL/min per 1.73 m2 were risks higher among ACE-I/ARB users. We developed a hyperkalemia susceptibility score that incorporated estimated glomerular filtration rate, baseline potassium level, sex, diabetes mellitus, heart failure, and the concomitant use of potassium-sparing diuretics in new ACE-I/ARB users; this score accurately predicted 1-year hyperkalemia risk in the SCREAM cohort (area under the curve, 0.845, 95% CI: 0.840-0.869) and in a validation cohort from the US-based Geisinger Health System (N=19 524; area under the curve, 0.818, 95% CI: 0.794-0.841), with good calibration. CONCLUSIONS:
Hyperkalemia within the first year of ACE-I/ARB therapy was relatively uncommon among people with estimated glomerular filtration rate >60 mL/min per 1.73 m2, but rates were much higher with lower estimated glomerular filtration rate. Use of the hyperkalemia susceptibility score may help guide laboratory monitoring and prescribing strategies.
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Authors | Ghassan Bandak, Yingying Sang, Alessandro Gasparini, Alex R Chang, Shoshana H Ballew, Marie Evans, Johan Arnlov, Lars H Lund, Lesley A Inker, Josef Coresh, Juan-Jesus Carrero, Morgan E Grams |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 6
Issue 7
(Jul 19 2017)
ISSN: 2047-9980 [Electronic] England |
PMID | 28724651
(Publication Type: Journal Article, Validation Study)
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Copyright | © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. |
Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
- Biomarkers
- Creatinine
- Potassium
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Topics |
- Adult
- Aged
- Angiotensin II Type 1 Receptor Blockers
(adverse effects)
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects)
- Biomarkers
(blood)
- Creatinine
(blood)
- Databases, Factual
- Drug Monitoring
(methods, standards)
- Female
- Glomerular Filtration Rate
(drug effects)
- Humans
- Hyperkalemia
(blood, chemically induced, diagnosis)
- Kidney
(drug effects, metabolism, physiopathology)
- Logistic Models
- Male
- Middle Aged
- Potassium
(blood)
- Predictive Value of Tests
- Propensity Score
- Renin-Angiotensin System
(drug effects)
- Reproducibility of Results
- Risk Factors
- Sweden
- Time Factors
- Treatment Outcome
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