Abstract | BACKGROUND: The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer. METHODS: RESULTS: A total of 14,331 patients met the inclusion criteria. Chemotherapy alone was delivered to 5464 patients (38.1%); 6418 (44.8%), 322 (2.3%), and 2127 (14.8%) received chemotherapy along with EBRT, IMRT, and SBRT, respectively. The unadjusted median survival before matching was 9.9, 10.9, 12.0, and 13.9 months for patients treated with chemotherapy, EBRT, IMRT, and SBRT, respectively. In separate matched analyses, SBRT remained superior to chemotherapy alone (log-rank P < .0001) and EBRT (log-rank P = .0180). After matching, survival did not differ between patients receiving IMRT and patients receiving SBRT (log-rank P = .0492). CONCLUSIONS: SBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158-4167. © 2017 American Cancer Society.
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Authors | Susanna W L de Geus, Mariam F Eskander, Gyulnara G Kasumova, Sing Chau Ng, Tara S Kent, Joseph D Mancias, Mark P Callery, Anand Mahadevan, Jennifer F Tseng |
Journal | Cancer
(Cancer)
Vol. 123
Issue 21
Pg. 4158-4167
(Nov 01 2017)
ISSN: 1097-0142 [Electronic] United States |
PMID | 28708929
(Publication Type: Journal Article, Review)
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Copyright | © 2017 American Cancer Society. |
Chemical References |
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Topics |
- Adenocarcinoma
(mortality, radiotherapy, therapy)
- Aged
- Antineoplastic Agents
(therapeutic use)
- Chemoradiotherapy
(methods, statistics & numerical data)
- Databases, Factual
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Pancreatic Neoplasms
(mortality, radiotherapy, therapy)
- Propensity Score
- Radiosurgery
(methods, mortality, statistics & numerical data)
- Radiotherapy, Intensity-Modulated
(statistics & numerical data)
- Retrospective Studies
- Selection Bias
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