Core-Satellite Polydopamine-Gadolinium-Metallofullerene Nanotheranostics for Multimodal Imaging Guided Combination Cancer Therapy.

Abstract

Integration of magnetic resonance imaging (MRI) and other imaging modalities is promising to furnish complementary information for accurate cancer diagnosis and imaging-guided therapy. However, most gadolinium (Gd)-chelator MR contrast agents are limited by their relatively low relaxivity and high risk of released-Gd-ions-associated toxicity. Herein, a radionuclide-64 Cu-labeled doxorubicin-loaded polydopamine (PDA)-gadolinium-metallofullerene core-satellite nanotheranostic agent (denoted as CDPGM) is developed for MR/photoacoustic (PA)/positron emission tomography (PET) multimodal imaging-guided combination cancer therapy. In this system, the near-infrared (NIR)-absorbing PDA acts as a platform for the assembly of different moieties; Gd3 N@C80 , a kind of gadolinium metallofullerene with three Gd ions in one carbon cage, acts as a satellite anchoring on the surface of PDA. The as-prepared CDPGM NPs show good biocompatibility, strong NIR absorption, high relaxivity (r 1 = 14.06 mM-1 s-1 ), low risk of release of Gd ions, and NIR-triggered drug release. In vivo MR/PA/PET multimodal imaging confirms effective tumor accumulation of the CDPGM NPs. Moreover, upon NIR laser irradiation, the tumor is completely eliminated with combined chemo-photothermal therapy. These results suggest that the CDPGM NPs hold great promise for cancer theranostics.

• Authors: Sheng Wang, Jing Lin, Zhantong Wang, Zijian Zhou, Ruiliang Bai, Nan Lu, Yijing Liu, Xiao Fu, Orit Jacobson, Wenpei Fan, Junle Qu, Siping Chen, Tianfu Wang, Peng Huang, Xiaoyuan Chen
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 29 Issue 35 (Sep 2017) ISSN: 1521-4095 [Electronic] Germany
• PMID: 28703340 (Publication Type: Journal Article)
• Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Indoles
• Polymers
• polydopamine
• Gadolinium

Topics

• Gadolinium
• Humans
• Indoles (chemistry)
• Multimodal Imaging
• Neoplasms
• Phototherapy
• Polymers (chemistry)