Vitamin D deficiency impairs neurobehavioral development in male mice.

Abstract

Vitamin D deficiency is prevalent especially in pregnant women and children. Several studies found that vitamin D status was negatively correlated with risk of senile neurobehavioral abnormality. The aim of this study was to investigate the effects of vitamin D deficiency on neurobehavioral development in mice. In vitamin D deficiency group, dams and their male pups were fed with vitamin D deficient (VDD) diet, in which vitamin D was depleted. Anxiety-related behavior, depressive-like behavior, spatial learning and memory were measured. As expected, serum 25(OH)D level was reduced in VDD diet-fed mice. An anhedonia state, a key depressive-like behavior, was observed in VDD diet-fed mice. In open-field test, peripheral time was decreased and internal time was increased in VDD diet-fed mice. In elevated plus maze, the latency of the first entry into open arms was increased and the number of crossing in open arms was elevated in VDD diet-fed mice. Morris Water Maze showed that VDD-fed mice showed longer escape latency in the first six days. On the seventh day, escape latency was increased in VDD diet-fed mice. These results provide evidence that vitamin D deficiency impairs neurobehavioral development.

• Authors: Lin Fu, Yuan-Hua Chen, Xue Chen, Shen Xu, Zhen Yu, De-Xiang Xu
• Journal: Physiology & behavior (Physiol Behav) Vol. 179 Pg. 333-339 (Oct 01 2017) ISSN: 1873-507X [Electronic] United States
• PMID: 28700906 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Vitamin D
• Phosphorus
• Calcium

Topics

• Anhedonia
• Animals
• Animals, Newborn
• Anxiety (blood)
• Calcium (blood)
• Depression (blood)
• Diet
• Disease Models, Animal
• Male
• Maze Learning
• Mice, Inbred ICR
• Phosphorus (blood)
• Random Allocation
• Spatial Memory
• Vitamin D (blood)
• Vitamin D Deficiency (blood, psychology)