Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.

Abstract

Cisplatin is widely used as chemotherapeutic agent for treatment of diverse types of cancer, however, acute kidney injury (AKI) is an important side effect of this treatment. Diverse mechanisms have been involved in cisplatin-induced AKI, such as oxidative stress, apoptosis and mitochondrial damage. On the other hand, curcumin is a polyphenol extracted from the rhizome of Curcuma longa L. Previous studies have shown that curcumin protects against the cisplatin-induced AKI; however, it is unknown whether curcumin can reduce alterations in mitochondrial bioenergetics and dynamic in this model. It was found that curcumin prevents cisplatin-induced: (a) AKI and (b) alterations in the following mitochondrial parameters: bioenergetics, ultrastructure, hydrogen peroxide production and dynamic. In fact, curcumin prevented the increase of mitochondrial fission 1 protein (FIS1), the decrease of optic atrophy 1 protein (OPA1) and the decrease of NAD+-dependent deacetylase sirtuin-3 (SIRT3), a mitochondrial dynamic regulator as well as the increase in the mitophagy associated proteins parkin and phosphatase and tensin homologue (PTEN)-induced putative kinase protein 1 (PINK1). In conclusion, the protective effect of curcumin in cisplatin-induced AKI was associated with the prevention of the alterations in mitochondrial bioenergetics, ultrastructure, redox balance, dynamic, and SIRT3 levels.

• Authors: Bibiana Ortega-Domínguez, Omar Emiliano Aparicio-Trejo, Fernando E García-Arroyo, Juan Carlos León-Contreras, Edilia Tapia, Eduardo Molina-Jijón, Rogelio Hernández-Pando, Laura Gabriela Sánchez-Lozada, Diana Barrera-Oviedo, José Pedraza-Chaverri
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 107 Issue Pt A Pg. 373-385 (Sep 2017) ISSN: 1873-6351 [Electronic] England
• PMID: 28698153 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• FIS1 protein, mouse
• Mitochondrial Proteins
• Opa3 protein, mouse
• Plant Extracts
• Proteins
• Hydrogen Peroxide
• Ubiquitin-Protein Ligases
• parkin protein
• Curcumin
• Cisplatin

Topics

• Acute Kidney Injury (drug therapy, etiology, metabolism, physiopathology)
• Animals
• Antineoplastic Agents (adverse effects)
• Apoptosis (drug effects)
• Cisplatin (adverse effects)
• Curcuma (chemistry)
• Curcumin (administration & dosage)
• Energy Metabolism (drug effects)
• Humans
• Hydrogen Peroxide (metabolism)
• Kidney (drug effects, metabolism)
• Male
• Mitochondria (drug effects, metabolism)
• Mitochondrial Proteins (genetics, metabolism)
• Mitophagy (drug effects)
• Oxidative Stress (drug effects)
• Plant Extracts (administration & dosage)
• Proteins (genetics, metabolism)
• Rats
• Rats, Wistar
• Ubiquitin-Protein Ligases (genetics, metabolism)