Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: A randomized, double-blind, placebo-controlled, clinical trial.

Abstract

Although periodontal diseases are caused by some of the specific pathogens, most of the tissue damage is caused by the host reaction to disease and not actually by the infections. Therefore, host modulatory therapy (HMT) has advanced benefit for the treatment of periodontitis, which works basically by reducing tissue destruction and regeneration in periodontium by altering the critical aspects of host response regulation and up regulating defensive regenerative responses. The present study was conducted with the goal to test an innovative therapeutic option using chemically modified tetracycline in patients affected with generalized, moderate and severe chronic periodontitis. We assumed that CMT might have the potential to provoke an assessable clinical result and pharmacologically impede the level inflammatory flow. CMT (incyclinide) treated group had significantly higher CAL (clinical attachment) values than Placebo Control suggesting an improved CAL in CMT treatment. Host modulation therapy width incyclinide can be as an adjunct to conventional nonsurgical therapies without antimicrobial resistance. Progress was noticed in the clinical parameters but not the serum CRP level in our study establishing the role of CMTs in controlling chronic periodontitis. Also CMT treatment indicates its role in anti-inflammatory process as it inhibited IL-12 and TNF alpha but IL-10 level was not affected. However, more randomized placebo-controlled clinical trials with large sample size are required in order to authenticate the usage of CMTs in chronic periodontitis treatment. Based on this understanding, exploration of the novel, low-cost synthetic inhibitors that can be used as potential therapeutic agents, has been tested.

• Authors: Abdullah A Alyousef, Darshan Devang Divakar, Muzaheed
• Journal: Microbial pathogenesis (Microb Pathog) Vol. 110 Pg. 279-284 (Sep 2017) ISSN: 1096-1208 [Electronic] England
• PMID: 28687322 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Cytokines
• IL10 protein, human
• Placebos
• Tetracyclines
• Tumor Necrosis Factor-alpha
• Interleukin-10
• Interleukin-12

Topics

• Adolescent
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Child
• Chronic Periodontitis (drug therapy)
• Cytokines (drug effects, metabolism)
• Dental Plaque
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• India
• Interleukin-10 (metabolism)
• Interleukin-12 (metabolism)
• Male
• Middle Aged
• Oral Hygiene Index
• Periodontal Attachment Loss (drug therapy, therapy)
• Periodontal Index
• Periodontal Pocket (drug therapy, therapy)
• Placebos
• Stem Cells
• Tetracyclines (chemistry, therapeutic use)
• Treatment Outcome
• Tumor Necrosis Factor-alpha (drug effects)
• Young Adult