Regulation of MicroRNAs by Phytochemicals: A Promising Strategy for Cancer Chemoprevention.

Abstract

A growing body of evidence suggests that phytochemicals are potentially able to affect a variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis, inflammation, and DNA repair. Phytochemicals may typically play pleiotropic regulatory roles in cancer cells. Chemoprevention, which can be achieved by using these natural agents, has emerged as a helpful strategy to manage a variety of malignancies. With regard to cancer-associated chemopreventive mechanisms, phytochemicals can act by modulating microRNAs (miRNAs) and their target genes. This review aims to present an overview of recent findings on the effects of some wellcharacterized bioactive phytochemicals on miRNA regulation in different cancer types. The potential use of these phytochemicals for the chemoprevention and treatment of cancer is also discussed.

• Authors: Sadegh Babashah, Babak Bakhshinejad, Maryam Tahmasebi Birgani, Katayoon Pakravan, William C Cho
• Journal: Current cancer drug targets (Curr Cancer Drug Targets) Vol. 18 Issue 7 Pg. 640-651 ( 2018) ISSN: 1873-5576 [Electronic] Netherlands
• PMID: 28669335 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anticarcinogenic Agents
• MicroRNAs
• Phytochemicals

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Chemoprevention (methods)
• Gene Expression Regulation, Neoplastic
• Humans
• MicroRNAs (genetics)
• Molecular Targeted Therapy
• Neoplasms (prevention & control)
• Phytochemicals (therapeutic use)