Abstract | OBJECTIVE: Because diet components are important during dieting in obesity treatment, we examined possible beneficial effects of substituting corn oil and sugar with flaxseed oil and grape in calorie-restricted high-fat diets on weight changes as well as improvement in some metabolic markers and related gene expression. METHODS: Seventy-five C57BL/6J male mice were given free access to a high-fat (36% of energy from fat) diet containing corn oil plus sugar (CO + S). After 11 weeks, 15 mice were sacrificed and another 60 were divided among 4 high-fat diet groups with 30% calorie restriction (CR) for the next 12 weeks. The diets contained corn oil (CO) or flaxseed oil (FO) with sugar (S) or grape (G). RESULTS: CONCLUSIONS:
Sugar replacement with polyphenol-rich grape along with CR improved glucose homeostasis, and substituting corn oil with flaxseed oil in obese mice reduced fat mass, but even with no change in adiponectin levels it could not decrease insulin resistance. However, none of the food item combinations facilitated weight reduction in the long-term CR. Therefore, regardless of the total calorie intake, different diet components and fat contents may have unexpected effects on metabolic regulation.
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Authors | Hastimansooreh Ansar, Negar Zamaninour, Abolghassem Djazayery, Hamideh Pishva, Mohammadreza Vafa, Ramin Mazaheri Nezhad Fard, Aydin Dilmaghanian, Khadijeh Mirzaei, Farzad Shidfar |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 36
Issue 6
Pg. 422-433
(Aug 2017)
ISSN: 1541-1087 [Electronic] United States |
PMID | 28665260
(Publication Type: Journal Article)
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Chemical References |
- Polyphenols
- Sugars
- Linseed Oil
- Corn Oil
- Glucose
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Topics |
- Adipose Tissue
(drug effects)
- Animal Feed
(analysis)
- Animals
- Body Composition
- Caloric Restriction
- Corn Oil
(chemistry, pharmacology)
- Diet
- Diet, High-Fat
(adverse effects)
- Glucose
(metabolism)
- Homeostasis
- Linseed Oil
(chemistry, pharmacology)
- Male
- Mice
- Obesity
- Organ Size
- Polyphenols
(chemistry, pharmacology)
- Sugars
(administration & dosage)
- Vitis
(chemistry)
- Weight Loss
(drug effects)
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