Abstract | AIMS: METHOD: A retrospective survey of Ro52+Ro60- was carried out as part of the service evaluation of extractable nuclear antigen antibodies (ENA) reporting from the immunology laboratory, the NHS Greater Glasgow and Clyde (GGC), UK. The clinical documents and laboratory results of 97 patients with Ro52+Ro60- and 100 patients with Ro52+Ro60+ were reviewed. RESULTS: Seventy-one patients (73%) with anti Ro52+Ro60- antibodies have been diagnosed with autoimmune conditions including undifferentiated connective tissue diseases (n=14, 14%), systemic lupus erythematosus (n=10, 10%), Sjögren's syndrome (n=10, 10%) and rheumatoid arthritis (n=13, 13%). Twenty-three patients (24%) with anti Ro52+Ro60- antibodies have no autoimmune features but were found to have significant clinical conditions including malignancies. In contrast, 87 patients (87%) with anti Ro52+Ro60+ antibodies have autoimmune conditions including Sjögren's syndrome (n=34, 34%), systemic lupus erythematosus (SLE; n=23, 23%), undifferentiated connective tissue diseases (n=12, 12%) and rheumatoid arthritis (n=6, 6%). CONCLUSION: Anti Ro52 without anti Ro60 (Ro52+Ro60-) antibodies should be reported. In the majority of patients these autoantibodies were associated with various autoimmune diseases. Anti Ro52+Ro60- antibodies were also found in patients with significant clinical conditions including malignancies even though there was no suggestion of autoimmunity at the time of testing.
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Authors | Sai H K Murng, Moira Thomas |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 71
Issue 1
Pg. 12-19
(Jan 2018)
ISSN: 1472-4146 [Electronic] England |
PMID | 28663326
(Publication Type: Journal Article)
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Copyright | © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. |
Chemical References |
- Autoantibodies
- Ribonucleoproteins
- SS-A antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(immunology)
- Autoimmune Diseases
(immunology)
- Female
- Humans
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Middle Aged
- Retrospective Studies
- Ribonucleoproteins
(immunology)
- Sjogren's Syndrome
(immunology)
- Undifferentiated Connective Tissue Diseases
(immunology)
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