Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population.

Abstract

Aldosterone synthase (CYP11B2) is as an 9-exon gene on chromosome 8q22 and exists as a common single nucleotide polymorphism C-T transition for position -344. The aim of this study was to assess the -344T/C polymorphism of the aldosterone synthase promoter in a European continental ancestry congestive heart failure (CHF) population.

METHODS:

Patients discharged after an acute decompensation were enrolled and underwent echocardiography, determination of BNP, evaluation of non-invasive cardiac outputs and determination of -344 T/C SNP in the aldosterone synthase gene.

RESULTS:

175 patients (137 male; age 69.9 ± 10.2 years) were enrolled. The genotype distribution of -344 T/C SNP demonstrated a TT genotype in 61 patients (34.9%), CT in 80 (45.7%) and finally CC in 34 (19.4%) CHF patients. According to presence of C allele, CHF patients were divided into C group (-CT/CC genotype, 114 subjects) and T Group (-TT genotype, 61 subjects). The two groups did not differ in term of age, non-invasive cardiac output at rest, creatinine level or end-systolic or diastolic left ventricle diameter, LVEF and BNP. In group C patients in comparison than in group T a higher degree of disability (Barthel Index p = 0.004), NYHA class (p = 0.02) and a lower cardiac index (p = 0.01) emerged. Moreover, the two groups showed a similar clinical outcome (death for any cause/hospital readmission for CHF) at 48 month follow-up (p = 0.16; log-rank 1.99).

CONCLUSIONS:

In European continental ancestry patients the C allele (CC or CT) at -344T/C SNP in the aldosterone synthase gene does not significantly influence clinical prognosis of CHF.

• Authors: Mauro Feola, Martino Monteverde, Daniela Vivenza, Marzia Testa, Laura Leto, Valentina Astesana, Francesco Mussapi, Antonello Vado, Marco Merlano, Cristiana Lo Nigro
• Journal: Archives of medical research (Arch Med Res) Vol. 48 Issue 2 Pg. 156-161 (Feb 2017) ISSN: 1873-5487 [Electronic] United States
• PMID: 28625318 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 IMSS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Cytochrome P-450 CYP11B2

Topics

• Aged
• Cytochrome P-450 CYP11B2 (genetics)
• Female
• Gene Frequency
• Genotype
• Heart Failure (ethnology, genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Prognosis
• Promoter Regions, Genetic
• Prospective Studies
• White People