Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans.

Abstract

AIM:

To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits.

METHODS:

We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC, in blood DNA using the Infinium HumanMethylation450 (n = 100, a Korean COPD cohort).

RESULTS:

We found one significant DMP (cg03559389, DIP2C) and 104 significant DMRs after multiple-testing correction. Of these, 34 DMRs mapped to genes differential expressed with respect to the same trait. Five of the genes were associated with more than two traits: CTU2, USP36, ZNF516, KLK10 and CPT1B.

CONCLUSION:

We identified novel differential methylation loci related to COPD and lung function in blood DNA in Koreans and confirmed previous findings in non-Asians. Epigenetic modification could contribute to the etiology of these phenotypes.

• Authors: Mi Kyeong Lee, Yoonki Hong, Sun-Young Kim, Woo Jin Kim, Stephanie J London
• Journal: Epigenomics (Epigenomics) Vol. 9 Issue 7 Pg. 971-984 (07 2017) ISSN: 1750-192X [Electronic] England
• PMID: 28621160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Intramural)

Topics

• Aged
• Aged, 80 and over
• Case-Control Studies
• DNA Methylation
• Epigenesis, Genetic
• Female
• Genetic Loci
• Genome-Wide Association Study
• Humans
• Male
• Middle Aged
• Pulmonary Disease, Chronic Obstructive (genetics, pathology, physiopathology)