68Ga-PSMA-11 PET/CT in Newly Diagnosed Carcinoma of the Prostate: Correlation of Intraprostatic PSMA Uptake with Several Clinical Parameters.

Abstract

68Ga-prostate-specific membrane antigen (PSMA) PET/CT is a promising diagnostic tool for patients with prostate cancer. Our study evaluates SUVs in benign prostate tissue and malignant, intraprostatic tumor lesions and correlates results with several clinical parameters. Methods: One hundred four men with newly diagnosed prostate carcinoma and no previous therapy were included in this study. SUVmax was measured and correlated with biopsy findings and MRI. Afterward, data were compared with current prostate-specific antigen (PSA) values, Gleason score (GS), and d'Amico risk classification. Results: In this investigation a mean SUVmax of 1.88 ± 0.44 in healthy prostate tissue compared with 10.77 ± 8.45 in malignant prostate lesions (P < 0.001) was observed. Patients with higher PSA, higher GS, and higher d'Amico risk score had statistically significant higher PSMA uptake on PET/CT (P < 0.001 each). Conclusion: PSMA PET/CT is well suited for detecting the intraprostatic malignant lesion in patients with newly diagnosed prostate cancer. Our findings indicate a significant correlation of PSMA uptake with PSA, GS, and risk classification according to the d'Amico scale.

• Authors: Stefan A Koerber, Maximilian T Utzinger, Clemens Kratochwil, Claudia Kesch, Matthias F Haefner, Sonja Katayama, Walter Mier, Andrei H Iagaru, Klaus Herfarth, Uwe Haberkorn, Juergen Debus, Frederik L Giesel
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 58 Issue 12 Pg. 1943-1948 (12 2017) ISSN: 1535-5667 [Electronic] United States
• PMID: 28619734 (Publication Type: Journal Article)
• Copyright: © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Chemical References

• Antigens, Surface
• Gallium Isotopes
• Gallium Radioisotopes
• Oligopeptides
• Organometallic Compounds
• Radiopharmaceuticals
• gallium 68 PSMA-11
• Edetic Acid
• FOLH1 protein, human
• Glutamate Carboxypeptidase II

Topics

• Adult
• Aged
• Antigens, Surface (metabolism)
• Biopsy
• Edetic Acid (analogs & derivatives)
• Gallium Isotopes
• Gallium Radioisotopes
• Glutamate Carboxypeptidase II (metabolism)
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neoplasm Grading
• Oligopeptides
• Organometallic Compounds
• Positron Emission Tomography Computed Tomography (methods)
• Prostatic Neoplasms (diagnostic imaging, metabolism, radiotherapy)
• Radiopharmaceuticals
• Ultrasonography