Abstract | BACKGROUND: The aim of this review is to summarize the effects of various naturally occurring polyphenols in the management of metabolic dysfunctions. This cluster of metabolic abnormalities comprises insulin resistance, increased levels of free fatty acids, hypercholesterolemia, obesity, hyperglycemia and hypertension, diabetes mellitus (DM) type 1 (T1DM) and type 2 (T2DM) along with DM-induced complications. Most of them are included in the well-known metabolic syndrome (MS). These metabolic dysfunctions in turn are tightly associated to a high risk of development of cardiovascular diseases. Although molecular mechanisms underlying the onset of metabolic dysfunctions and related complications are not yet clear, it is widely recognized that they are associated to oxidative stress and chronic low-grade of inflammatory levels. METHODS: We undertook a structured search of bibliographic references through the use of SciFinder. The database was provided by a division of ACS (American Chemical Society) and guarantees access to the world's most extensive and authoritative source of references. The search was performed using " heme oxygenase-1" as research topic and a subsequent refinement was done by using inclusion/exclusion criteria. The quality of retrieved papers was evaluated on the basis of standard tools. RESULTS: CONCLUSION: The following review is intended to stimulate interest in the role of natural occurring HO-1 inducers in metabolic dysfunction, focusing on the clinical potential of HO-1 activity to restore the balance between pro-oxidant and anti-oxidants systems.
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Authors | Valeria Pittala, Luca Vanella, Loredana Salerno, Giuseppe Romeo, Agostino Marrazzo, Claudia Di Giacomo, Valeria Sorrenti |
Journal | Current medicinal chemistry
(Curr Med Chem)
Vol. 25
Issue 13
Pg. 1577-1595
( 2018)
ISSN: 1875-533X [Electronic] United Arab Emirates |
PMID | 28618991
(Publication Type: Journal Article, Review)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Antioxidants
- NF-E2-Related Factor 2
- Polyphenols
- Reactive Oxygen Species
- Heme Oxygenase-1
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Cardiovascular Diseases
(drug therapy, metabolism)
- Enzyme Induction
- Heme Oxygenase-1
(metabolism)
- Humans
- Metabolic Diseases
(drug therapy, metabolism)
- Metabolic Syndrome
(drug therapy, metabolism)
- NF-E2-Related Factor 2
(metabolism)
- Oxidation-Reduction
- Oxidative Stress
(drug effects)
- Polyphenols
(therapeutic use)
- Reactive Oxygen Species
(metabolism)
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