Diagnostic sensitivity of abdominal fat aspiration in cardiac amyloidosis.

Abstract

AIMS:

Congo red staining of an endomyocardial biopsy is the diagnostic gold-standard in suspected cardiac amyloidosis (CA), but the procedure is associated with the risk, albeit small, of serious complications, and delay in diagnosis due to the requirement for technical expertise. In contrast, abdominal fat pad fine needle aspiration (FPFNA) is a simple, safe and well-established procedure in systemic amyloidosis, but its diagnostic sensitivity in patients with suspected CA remains unclear.

METHODS AND RESULTS:

We assessed the diagnostic sensitivity of FPFNA in 600 consecutive patients diagnosed with CA [216 AL amyloidosis, 113 hereditary transthyretin (ATTRm), and 271 wild-type transthyretin (ATTRwt) amyloidosis] at our Centre. Amyloid was detected on Congo red staining of FPFNAs in 181/216 (84%) patients with cardiac AL amyloidosis, including 100, 97, and 78% of those with a large, moderate, and small whole-body amyloid burden, respectively, as assessed by serum amyloid P (SAP) component scintigraphy (P < 0.001); the deposits were successfully typed as AL by immunohistochemistry in 102/216 (47%) cases. Amyloid was detected in FPFNAs of 51/113 (45%) patients with ATTRm CA, and only 42/271 (15%) cases with ATTRwt CA.

CONCLUSIONS:

FPFNA has reasonable diagnostic sensitivity in cardiac AL amyloidosis, particularly in patients with a large whole-body amyloid burden. Although the diagnostic sensitivity of FPFNA is substantially lower in transthyretin CA, particularly ATTRwt, it may nevertheless sometimes obviate the need for endomyocardial biopsy.

• Authors: Candida Cristina Quarta, Esther Gonzalez-Lopez, Janet A Gilbertson, Nichola Botcher, Dorota Rowczenio, Aviva Petrie, Tamer Rezk, Taryn Youngstein, Shameem Mahmood, Sajitha Sachchithanantham, Helen J Lachmann, Marianna Fontana, Carol J Whelan, Ashutosh D Wechalekar, Philip N Hawkins, Julian D Gillmore
• Journal: European heart journal (Eur Heart J) Vol. 38 Issue 24 Pg. 1905-1908 (Jun 21 2017) ISSN: 1522-9645 [Electronic] England
• PMID: 28605421 (Publication Type: Evaluation Study, Journal Article)
• Copyright: © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology.

Chemical References

• Iodine Radioisotopes
• Serum Amyloid P-Component
• Congo Red

Topics

• Abdominal Fat (pathology)
• Aged
• Amyloid Neuropathies, Familial (diagnosis)
• Amyloidosis (pathology)
• Biopsy, Fine-Needle (methods)
• Cardiomyopathies (pathology)
• Congo Red
• Female
• Humans
• Iodine Radioisotopes
• Male
• Radionuclide Imaging (methods)
• Sensitivity and Specificity
• Serum Amyloid P-Component