Extremely Locally Advanced Ovarian Malignant Mixed Mullerian Tumor in 37-Years-Old Female.

Abstract

Ovarian carcinosarcomas, rare variant of ovarian carcinoma, composed of both carcinomatous and mesenchymal components, solid and/or cystic, fleshy and hemorrhagic, frequently spreading beyond the ovary, are treated with surgery and adjuvant chemotherapy according to the treatment principles of ovarian carcinomas due to the small number of reported cases and lack of randomized studies. We report a case of a 37-year-old woman with clinical signs of extremely locally advanced tumor of ovarian origin, infiltrating the lower left quadrant of the abdominal wall with necrosis of the covering skin. Prior biopsy of the left ovary and omentum confirmed poorly differentiated serous adenocarcinoma. Bulky tumor the size of a child's head, originating from the left ovary and infiltrating into the lower left quadrant abdominal wall was debulked with wide excision of the abdominal wall and creation of wide defect of the lower left part of abdominal wall covered with Dexon mesh. After the recovery, the medial part of the defect with exposed mesh was closed with pedicled tensor fasciae latae fasciomyocutaneous flap, while the lateral part of the defect was covered with split thickness skin graft. Optimal surgical cytoreduction and adjuvant chemotherapy in case of extremely locally advanced ovarian malignant Müllerian tumor provide satisfactory recurrence-free survival period.

• Authors: Gjorgji Jota, Radomir Gelevski, Zoran Karadzov, Redzep Selmani, Magdalena Genadieva-Dimitrova, Margarita Peneva, Vesna Jovanovska-Manevska
• Journal: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) (Pril (Makedon Akad Nauk Umet Odd Med Nauki)) Vol. 38 Issue 1 Pg. 75-79 (Mar 01 2017) ISSN: 1857-9345 [Print] North Macedonia
• PMID: 28593890 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Carcinosarcoma (pathology, therapy)
• Chemotherapy, Adjuvant
• Cytoreduction Surgical Procedures
• Female
• Humans
• Mixed Tumor, Mullerian (pathology, therapy)
• Neoplasm Invasiveness
• Ovarian Neoplasms (pathology, therapy)
• Treatment Outcome
• Tumor Burden