Abstract | OBJECTIVE: METHODS: We retrospect the consecutive medical files of T2DM patients. Nerve conduction velocity (NCV), vibration perception threshold (VPT) and the data for complete blood count were recorded. Patients were divided into tertiles based on admission NLR values. Clinical parameters were firstly compared among groups. Then, logistic regression and ROC analysis were performed. RESULTS: Percentages of DPN were 42.60%, 54.97% and 65.50%, in the low, middle and high tertile, respectively (n=72, 94 and 112, p<0.05). VPT values were 13.75±7.97, 15.01±9.60 and 16.78±10.92, respectively, (p<0.05). NCV in different nerves decreased with the increase of NLR (p<0.05). After adjusting potential related factors, NLR was still related to status of DPN in the logistic regression (r=1.743, p=0.001). Area under ROC was 0.619 (p<0.001). CONCLUSION: The present study showed that T2DM patients with higher NLR levels might be more likely to develop peripheral neuropathy complication. NLR levels grow with the increase of NCV and VPT results. As a predictor of DPN, NLR could be used in clinical practice to help doctors understand the level of DPN progression.
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Authors | Siying Liu, Hangping Zheng, Xiaoming Zhu, Fei Mao, Shuo Zhang, Hongli Shi, Yiming Li, Bin Lu |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 130
Pg. 90-97
(Aug 2017)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 28582723
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier B.V. |
Topics |
- Adult
- Aged
- Diabetes Mellitus, Type 2
(blood, complications)
- Diabetic Neuropathies
(blood, physiopathology)
- Female
- Humans
- Leukocyte Count
- Lymphocytes
- Male
- Middle Aged
- Neural Conduction
- Neutrophils
- Perception
(physiology)
- Peripheral Nervous System Diseases
(blood)
- ROC Curve
- Retrospective Studies
- Vibration
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