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The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines.

Abstract
The present study tried for a phyto-synthetic method of producing silver nanoparticles (Ag-NPs) with size controlled as and eco-friendly route that can lead to their advanced production with decorative tranquil morphology. By inducing temperature fluctuation of the reaction mixture from 25 to 80°C the plasmon resonance band raised slowly which had an ultimate effect on size and shape of Ag-NPs as shown by UV-visible spectroscopy and TEM results. The biosynthesized nanoparticles showed good cytotoxic impact against MCF-7, A549 and Hep2 cells compared to normal cell lines. Compared to control plates, the percentage of cell growth inhibition was found to be high with as concentrations of Ag-NPs becomes more as determined by MTT assay. The AO/EtBr staining observations demonstrated that the mechanism of cell death induced by Ag-NPs was due to apoptosis in cancer cells. These present results propose that the silver nanoparticles (Ag-NPs) may be utilized as anticancer agents for the treatment of various cancer types. However, there is a need for study of in vivo examination of these nanoparticles to find their role and mechanism inside human body. Further, studies we plan to do biomarker fabrication from the green synthesized plant extract nanoparticles like silver, gold and copper nanoparticles with optimized shape and sizes and their enhancement of these noble nanoparticles.
AuthorsK Venugopal, H Ahmad, E Manikandan, K Thanigai Arul, K Kavitha, M K Moodley, K Rajagopal, R Balabhaskar, M Bhaskar
JournalJournal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 173 Pg. 99-107 (Aug 2017) ISSN: 1873-2682 [Electronic] Switzerland
PMID28570910 (Publication Type: Journal Article)
CopyrightCopyright © 2017. Published by Elsevier B.V.
Chemical References
  • Antineoplastic Agents
  • Plant Extracts
  • Silver
Topics
  • A549 Cells
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Apoptosis (drug effects)
  • Beta vulgaris (chemistry, metabolism)
  • Cell Line, Tumor
  • Green Chemistry Technology
  • Humans
  • MCF-7 Cells
  • Metal Nanoparticles (chemistry)
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Particle Size
  • Plant Extracts (chemistry)
  • Silver (chemistry)
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared

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