Urinary F2-isoprostanes and the risk of hypertension.

Abstract

PURPOSE:

There is strong biological plausibility for a causal role of reactive oxygen species in vascular pathology but no direct epidemiological evidence linking elevated reactive oxygen species levels to hypertension development. We examined cross-sectional and prospective associations between oxidative status (urinary F2-isoprostanes) and hypertension in the Insulin Resistance Atherosclerosis Study cohort (n = 831).

METHODS:

The cohort included non-Hispanic white, Hispanic, and non-Hispanic black individuals, with 252 (30%) having prevalent hypertension and 579 participants normotensive at baseline, 122 (21%) of whom developed hypertension during the 5-year follow-up. Four urinary F2-isoprostane isomers were quantified in baseline specimens using LC/MS-MS and were summarized as a composite index. Examined outcomes included hypertension status (yes/no), systolic (SBP) and diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP).

RESULTS:

Prevalent and incident hypertension were associated with greater age, Black race, impaired glucose tolerance, and greater BMI. F2-IsoP levels were lower among men and among non-Hispanic Blacks, were inversely associated with age, and were directly associated with BMI. No cross-sectional association was found between F2-isoprostanes and hypertension status (OR = 0.93, 0.77-0.12). Among the continuous measures of blood pressure only PP was associated with F2-isoprostanes at baseline (beta-coefficient = 0.99, 0.11-1.86). No prospective association was found between F2-isoprostanes and incident hypertension: OR = 0.98, 0.77-1.25. No prospective associations were found for systolic blood pressure and diastolic blood pressure, and pulse pressure. Mean arterial pressure showed an inverse association (beta-coefficient = -0.16, -0.31 to -0.01).

CONCLUSIONS:

Elevated F2-isoprostane levels do not increase the risk of hypertension.

• Authors: Charles David Melton, Ruiyan Luo, Brett J Wong, Ivan Spasojevic, Lynne E Wagenknecht, Ralph B D'Agostino Jr, Dora Il'yasova
• Journal: Annals of epidemiology (Ann Epidemiol) Vol. 27 Issue 6 Pg. 391-396 (06 2017) ISSN: 1873-2585 [Electronic] United States
• PMID: 28558917 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• F2-Isoprostanes

Topics

• Adult
• Black or African American (statistics & numerical data)
• Blood Pressure (physiology)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (epidemiology, urine)
• F2-Isoprostanes (urine)
• Female
• Hispanic or Latino (statistics & numerical data)
• Humans
• Hypertension (complications, epidemiology)
• Incidence
• Insulin Resistance
• Lipid Peroxidation
• Male
• Middle Aged
• Oxidative Stress (physiology)
• Prospective Studies
• Risk Factors
• United States (epidemiology)
• White People (statistics & numerical data)