Antitumoral effect of vanadium compounds in malignant melanoma cell lines.

Abstract

In this study we evaluated the anticancer activity against malignant melanoma (MM) of four different vanadium species: the inorganic anion vanadate(V) (indicated with VN), and three oxidovanadium(IV) complexes, [VIVO(dhp)2] where dhp- is the anion 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate (indicated with VS2), [VIVO(mpp)2] where mpp- is 1-methyl-3-hydroxy-4(1H)-pyridinonate (indicated with VS3), and [VIVO(ppp)2] where ppp- is 1-phenyl-2-methyl-3-hydroxy-4(1H)-pyridinonate (indicated with VS4). The antitumor effects of these compounds were studied against two different MM cell lines (A375 and CN-mel) and a fibroblast cell line (BJ) as normal control. All tested V compounds exert antiproliferative activity on MM cells in a dose dependent manner (IC50 ranges from 2.4μM up to 14μM) being A375 the most sensitive cell line. VN and VS2 were the two most active compounds against A375 (IC50 of 4.7 and 2.6μM, respectively), causing apoptosis and cell cycle block. The experimental data indicate that the cell cycle arrest occurs at different phases for the two V species analyzed (G2 checkpoint for VN and G0/G1 for VS2), showing the importance of the chemical form in determining their mechanism of action. These results add more insights into the landscape of vanadium versatility in biological systems and into its role as a potential cancer therapeutic agent.

• Authors: Carla Rozzo, Daniele Sanna, Eugenio Garribba, Maria Serra, Alessio Cantara, Giuseppe Palmieri, Marina Pisano
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 174 Pg. 14-24 (09 2017) ISSN: 1873-3344 [Electronic] United States
• PMID: 28558258 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Antineoplastic Agents
• Coordination Complexes
• Vanadium

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Cycle Checkpoints (drug effects)
• Cell Line, Tumor
• Coordination Complexes (chemical synthesis, chemistry, pharmacology)
• Humans
• Melanoma (drug therapy, metabolism, pathology)
• Vanadium (chemistry, pharmacology)