Abstract | PURPOSE: The purpose of this study is to evaluate, in a randomized clinical trial, the effects of metformin immediate release (IR) compared with metformin extended release (XR) on the gastrointestinal tolerability and glycemic control. MATERIALS AND METHODS: We enrolled 253 Caucasian patients with type 2 diabetes not well controlled by diet ( glycated hemoglobin [HbA1c] >7.0% and <8.5%). Patients were randomized to metformin IR or metformin XR for a period of 6 months at the maximum tolerated dose. The average dose of metformin IR used was 2,000±1,000 mg/day, while that of metformin XR was 1,000±500 mg/day. We evaluated body weight, HbA1c, fasting and postprandial glucose, fasting plasma insulin (FPI) and homeostasis model assessment insulin resistance (HOMA-IR), lipid profile, and levels of some adipocytokines, including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein ( hs-CRP), visfatin, and vaspin. Moreover, at the baseline and after 6 months, we administered patients some validated questionnaires to assess patients' satisfaction toward treatments. RESULTS: CONCLUSION:
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Authors | Giuseppe Derosa, Angela D'Angelo, Davide Romano, Pamela Maffioli |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 11
Pg. 1481-1488
( 2017)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 28553078
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adipokines
- Blood Glucose
- Delayed-Action Preparations
- Glycated Hemoglobin A
- Hypoglycemic Agents
- C-Reactive Protein
- Metformin
- Nicotinamide Phosphoribosyltransferase
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Topics |
- Adipokines
(metabolism)
- Aged
- Blood Glucose
(drug effects)
- Body Mass Index
- Body Weight
(drug effects)
- C-Reactive Protein
(metabolism)
- Delayed-Action Preparations
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Liberation
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Insulin Resistance
- Male
- Metformin
(administration & dosage, therapeutic use)
- Middle Aged
- Nicotinamide Phosphoribosyltransferase
(metabolism)
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