Abstract | INTRODUCTION: DEVELOPMENT: Currently we now know that different polymorphisms of PCSK9 are associated with the occurrence of ischaemic stroke. On the other hand, PCSK9 inhibitors prevent binding of PCSK9 to LDLR and inhibit degradation of LDLR, which results in increased hepatic uptake of LDL and lower LDL levels in blood. Different phase 2 and 3 studies, including OSLER and ODYSSEY LONG-TERM, have demonstrated the efficacy and safety of the new monoclonal antibodies against PCSK9 such as evolucumab and alirocumab, and the first exploratory analyses have shown evidence of their efficacy in decreasing vascular events, including stroke. CONCLUSIONS: Although few strokes have been reported by these studies, new ongoing trials examining the cardiovascular effects of evolucumab (FOURIER study), alirocumab (ODYSSEY OUTCOMES study), and bococizumab (SPIRE-1 and SPIRE-2 studies) will reveal the true potential of these drugs, particularly for the prevention of stroke.
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Authors | L Castilla-Guerra, M C Fernández-Moreno, M A Rico-Corral |
Journal | Neurologia (Barcelona, Spain)
(Neurologia (Engl Ed))
Vol. 34
Issue 3
Pg. 198-203
(Apr 2019)
ISSN: 2173-5808 [Electronic] Spain |
Vernacular Title | Colesterol e ictus: papel de los inhibidores de la proproteína convertasa subtilisina/kexina tipo 9. |
PMID | 28549755
(Publication Type: Journal Article, Systematic Review)
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Copyright | Copyright © 2017 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved. |
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Anticholesteremic Agents
- Cholesterol, LDL
- LDLR protein, human
- PCSK9 Inhibitors
- Receptors, LDL
- bococizumab
- PCSK9 protein, human
- Proprotein Convertase 9
- alirocumab
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Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Anticholesteremic Agents
(therapeutic use)
- Cholesterol, LDL
(metabolism)
- Humans
- PCSK9 Inhibitors
- Proprotein Convertase 9
(genetics)
- Receptors, LDL
(genetics)
- Stroke
(prevention & control)
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