Survival without peripheral neuropathy after massive acute arsenic poisoning: Treated by 2,3-dimercaptopropane-1-sulphonate.

Abstract

WHAT IS KNOWN AND OBJECTIVE:

Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited.

CASE DESCRIPTION:

A 37-year-old woman attempted suicide by ingesting 37.5 g of arsenic trioxide. DMPS was promptly initiated based on history and clinical symptoms. The patient recovered completely, with no complications or side effects of the therapy.

WHAT IS NEW AND CONCLUSION:

TDMPS is useful for the treatment of massive acute arsenic poisoning.

• Authors: P-H Lu, J-C Tseng, C-K Chen, C-H Chen
• Journal: Journal of clinical pharmacy and therapeutics (J Clin Pharm Ther) Vol. 42 Issue 4 Pg. 506-508 (Aug 2017) ISSN: 1365-2710 [Electronic] England
• PMID: 28547870 (Publication Type: Case Reports)
• Copyright: © 2017 John Wiley & Sons Ltd.

Chemical References

• Arsenicals
• Chelating Agents
• Oxides
• Unithiol
• Arsenic Trioxide

Topics

• Adult
• Arsenic Poisoning (drug therapy)
• Arsenic Trioxide
• Arsenicals
• Chelating Agents (therapeutic use)
• Female
• Humans
• Oxides (poisoning)
• Peripheral Nervous System Diseases (chemically induced, drug therapy)
• Suicide, Attempted
• Treatment Outcome
• Unithiol (therapeutic use)