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Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells.

Abstract
The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1 × 106 cells per rat), and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and DM) and autologous ADSC transplantation could partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared with DM+ADSC, significant improvement in cardiac functions can be observed in DM+ADSC+E in echocardiographic data, histological observations, and even cellular protein expression. Oral green tea EGCG administration and autologous ADSC transplantation show synergistically beneficial effects on diabetic cardiac myopathy in DM rats.NEW & NOTEWORTHY Cardiomyopathy can be induced in rats with diabetes mellitus (DM). Heart function can be restored in DM rats with adipose-derived stem cell treatment. Oral epigallocatechin gallate (EGCG) administration synergistically enhances cardiac function in DM rats with stem cell treatment. The EGCG and stem cell treatment cross-effect occurs via survival protein expression.
AuthorsTung-Sheng Chen, Show-Yih Liou, Chia-Hua Kuo, Lung-Fa Pan, Yu-Lan Yeh, Jeffery Liou, V Vijaya Padma, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
JournalJournal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol (1985)) Vol. 123 Issue 5 Pg. 1081-1091 (Nov 01 2017) ISSN: 1522-1601 [Electronic] United States
PMID28546469 (Publication Type: Journal Article)
CopyrightCopyright © 2017 the American Physiological Society.
Chemical References
  • Biomarkers
  • Blood Glucose
  • Catechin
  • epigallocatechin gallate
Topics
  • Adipose Tissue (cytology, metabolism, transplantation)
  • Administration, Oral
  • Animals
  • Apoptosis (drug effects)
  • Biomarkers (metabolism)
  • Blood Glucose (metabolism)
  • Catechin (administration & dosage, analogs & derivatives)
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Combined Modality Therapy
  • Diabetes Mellitus, Experimental (blood, complications, therapy)
  • Diabetic Cardiomyopathies (diagnostic imaging, etiology, physiopathology, prevention & control)
  • Echocardiography
  • Male
  • Myocytes, Cardiac (drug effects, metabolism, pathology)
  • Rats, Wistar
  • Recovery of Function
  • Signal Transduction (drug effects)
  • Stem Cell Transplantation

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