Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: a single-center, retrospective, observational study.

Abstract

Objective:

Autologous stem cell transplantation is an important strategy for patients with relapsed or refractory lymphoma. Although various regimens for peripheral blood stem cell collection have been used, the optimal regimen has not yet been established. We aimed to evaluate the mobilization efficacy and safety of the regimen consisted of etoposide and cytarabine (EC regimen).

Methods:

We retrospectively analyzed the clinical data of 46 lymphoma patients who received peripheral blood stem cell mobilization with the EC regimen [etoposide (100 mg/m2/day, days 1-4) and cytarabine (100 mg/m2/day, days 1-4)] at Toyohashi municipal hospital from 2004 to 2013.

Results:

The median age of the patients was 55 years. The most common underlying diseases were diffuse large B-cell lymphoma (46%) and follicular lymphoma (26%). Three-quarters of patients were in their second complete or partial remission. The median total number of collected CD34+ cells was 10.6 × 106 kg-1. Forty-two patients (91%) yielded at least 2 × 106 kg-1 CD34+ cells within a median of 2 apheresis days, and 33 patients (72%) achieved it with only one apheresis. Successful mobilization was observed in five of six patients who failed to mobilize previously. Although febrile neutropenia occurred in 22 patients (48%), no fatal infection was observed.

Conclusion:

The EC regimen was highly effective in lymphoma patients, including patients who mobilized poorly with other regimens.

• Authors: Daisuke Koyama, Satoshi Nishiwaki, Yasuhiko Harada, Satomi Yamamoto, Shingo Kurahashi, Takumi Sugimoto, Toshihiro Iwasaki, Isamu Sugiura
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 47 Issue 9 Pg. 820-825 (09 01 2017) ISSN: 1465-3621 [Electronic] England
• PMID: 28541555 (Publication Type: Journal Article)
• Copyright: © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• Antimetabolites, Antineoplastic
• Cytarabine
• Etoposide

Topics

• Adolescent
• Antimetabolites, Antineoplastic (administration & dosage, pharmacology, therapeutic use)
• Cytarabine (administration & dosage, pharmacology, therapeutic use)
• Etoposide (administration & dosage, pharmacology, therapeutic use)
• Female
• Hematopoietic Stem Cell Mobilization (methods)
• Hematopoietic Stem Cell Transplantation (methods)
• Humans
• Lymphoma, Large B-Cell, Diffuse (drug therapy, pathology)
• Male
• Middle Aged
• Retrospective Studies
• Transplantation Conditioning (methods)
• Transplantation, Autologous (methods)