Efficacy of Cyclosporine After Autologous Noncultured Melanocyte Transplantation in Localized Stable Vitiligo-A Pilot, Open Label, Comparative Study.

Abstract

BACKGROUND:

Understanding the pathogenesis of vitiligo has lead to innovation of new drugs and new uses of the existing drugs to enhance treatment outcome.

OBJECTIVE:

The aim of this observational pilot study was to assess the role of cyclosporine (CsA) to tackle the commonest aesthetic problem "perilesional halo" after autologous noncultured melanocyte-keratinocyte cell transplant (NCMKT) for localized, stable vitiligo.

MATERIALS AND METHODS:

Of the total 50 enrolled patients who underwent NCMKT for stable/resistant vitiligo, aged 12 to 68 years (mean 29.92 years), 18 were male and 32 were female. Group I (n = 25) patients did not receive any postoperative treatment. Group II (n = 25) patients received CsA postoperatively at 3 mg·kg·d for 3 weeks followed by 1.5 mg·kg·d for 6 weeks.

RESULTS:

In Group I, results were as follows: 28% (n = 7) achieved >75% repigmentation, 16% (n = 4) achieved 50% to 75% repigmentation, 52% (n = 13) achieved 25% to 50% repigmentation, and 4% (n = 1) achieved <25% repigmentation. In Group II, 100% (n = 25) achieved >75% (median 90.7%) repigmentation post-NCMKT at the end of 6 months.

CONCLUSION:

This new drug regimen using CsA resulted in rapid and uniform repigmentation without leaving any perilesional halo in Group II patients after NCMKT.

• Authors: Sharad Mutalik, Swapnil Shah, Varsha Sidwadkar, Meenaz Khoja
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 43 Issue 11 Pg. 1339-1347 (Nov 2017) ISSN: 1524-4725 [Electronic] United States
• PMID: 28538030 (Publication Type: Journal Article, Observational Study)

Chemical References

• Dermatologic Agents
• Cyclosporine

Topics

• Adolescent
• Adult
• Aged
• Child
• Combined Modality Therapy
• Cyclosporine (therapeutic use)
• Dermatologic Agents (therapeutic use)
• Female
• Humans
• Male
• Melanocytes (transplantation)
• Middle Aged
• Pilot Projects
• Prospective Studies
• Transplantation, Autologous
• Treatment Outcome
• Vitiligo (therapy)