Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of
low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords:
oral lichen planus,
laser therapy, low-level laser therapy, and
phototherapy. Owing to heterogeneity of data, no statistical analyses were conducted. Initially, 227 publications were identified. After selection, only six studies were included in this systematic review. In these studies, the
laser wavelengths, power output, and duration of irradiation ranged between 630-980 nm, 20-300 mW, and 10 s-15 min, respectively. All of the included studies found
laser to be effective in management of OLP, without any reported adverse effects. The results of the included studies confirm that
low-level laser therapy is effective in management of symptomatic OLP and can be used as an alternative to
corticosteroids. However, due to variety of methods and substantial variations in
laser parameters among these studies, more randomized clinical trials with large sample sizes are highly warranted.