Effects of topical ketorolac tromethamine 0.45% on intraoperative miosis and prostaglandin E2 release during femtosecond laser-assisted cataract surgery.

Abstract

PURPOSE:

To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser-assisted cataract surgery.

SETTING:

Seoul St. Mary's Hospital, Seoul, Korea.

DESIGN:

Prospective case series.

METHODS:

The study comprised the following 3 groups: conventional cataract surgery without topical NSAIDs (conventional group); femtosecond laser-assisted cataract surgery with preoperative topical ketorolac tromethamine 0.45% (femtosecond NSAID group), and femtosecond laser-assisted cataract surgery without topical NSAIDs (femtosecond no-NSAID group). To measure the aqueous humor PGE2 concentration, a 100 μL aqueous humor sample was collected from the anterior chamber after femtosecond laser pretreatment. The PGE2 concentration was measured using an enzyme immunoassay.

RESULTS:

Topical ketorolac tromethamine 0.45% led to a significant reduction in intraoperative miosis in the femtosecond NSAID group compared with the femtosecond no-NSAID group (P < .001). Absolute and relative reductions in pupil area in the femtosecond NSAID group were significantly lower than in the femtosecond no-NSAID group (P = .019 and P = .007, respectively). The mean aqueous humor PGE2 concentrations were 893.60 pg/mL ± 843.10 (SD) in the conventional group, 1911.43 ± 1178.63 pg/mL in the femtosecond NSAID group, and 743.63 ± 927.46 pg/mL in the femtosecond no-NSAID group (P < .001, conventional versus femtosecond NSAID and femtosecond NSAID versus femtosecond no NSAID; P > .05, conventional versus femtosecond NSAID).

CONCLUSION:

Preoperative topical ketorolac tromethamine 0.45% reduced miosis induced by femtosecond laser pretreatment and inhibited aqueous humor PGE2 elevation.

• Authors: Jong Hwa Jun, Young-Sik Yoo, Sung A Lim, Choun-Ki Joo
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 43 Issue 4 Pg. 492-497 (04 2017) ISSN: 1873-4502 [Electronic] United States
• PMID: 28532934 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Prostaglandins E
• Ketorolac Tromethamine

Topics

• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Cataract Extraction
• Humans
• Ketorolac Tromethamine (administration & dosage)
• Lasers
• Miosis (surgery)
• Prospective Studies
• Prostaglandins E (metabolism)
• Pupil