IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.

Abstract

Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.

• Authors: Zvi Laron, Rivka Kauli, Lena Lapkina, Haim Werner
• Journal: Mutation research. Reviews in mutation research (Mutat Res Rev Mutat Res) 2017 Apr - Jun Vol. 772 Pg. 123-133 ISSN: 1388-2139 [Electronic] Netherlands
• PMID: 28528685 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Receptors, Somatotropin
• Insulin-Like Growth Factor I

Topics

• Adolescent
• Adult
• Child
• Cohort Studies
• Exons
• Female
• Gene Deletion
• Humans
• Insulin-Like Growth Factor I (deficiency, genetics, pharmacology)
• Israel
• Laron Syndrome (complications, genetics)
• Longevity
• Male
• Middle Aged
• Mutation
• Neoplasms (genetics)
• Obesity (complications, genetics)
• Pedigree
• Receptors, Somatotropin (genetics, metabolism)
• Young Adult