Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats.

Abstract

Preclinical Research Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017. © 2017 Wiley Periodicals, Inc.

• Authors: Xiujie Liu, Jing Su, Yu Shi, Ying Guo, Imran Suheryani, Shicong Zhao, Yulin Deng, Weiwei Meng, Yan Chen, Lili Sun, Rongji Dai
• Journal: Drug development research (Drug Dev Res) Vol. 78 Issue 3-4 Pg. 155-163 (06 2017) ISSN: 1098-2299 [Electronic] United States
• PMID: 28524372 (Publication Type: Journal Article)
• Copyright: © 2017 Wiley Periodicals, Inc.

Chemical References

• Actins
• Drugs, Chinese Herbal
• Transforming Growth Factor beta
• smooth muscle actin, rat
• Dimethylnitrosamine

Topics

• Actins (metabolism)
• Animals
• Cell Line
• Chemical and Drug Induced Liver Injury (metabolism, prevention & control)
• Dimethylnitrosamine (adverse effects)
• Disease Models, Animal
• Drugs, Chinese Herbal (administration & dosage, pharmacology)
• Female
• Humans
• Male
• Rats
• Rats, Sprague-Dawley
• Transforming Growth Factor beta (metabolism)