Abstract | BACKGROUND: Whether post-anticoagulation D-dimer levels are useful in predicting recurrence in elderly patients with unprovoked venous thromboembolism is unknown. METHODS: RESULTS: There was no statistically significant association between quantitative or dichotomized D-dimer levels and venous thromboembolism recurrence. The area under the receiver operating characteristic curve for predicting recurrent venous thromboembolism was moderate (0.66; 95% confidence interval [CI], 0.51-0.82). The negative likelihood ratios were 0.34 (95% CI, 0.05-2.38) at the usual and 0.34 (95% CI, 0.09-1.29) at the age-adjusted cutoff values. Among patients with normal D-dimer results, venous thromboembolism recurrence rates were 6.8 (95% CI, 2.2-21.2) per 100 patient-years using the usual and 7.1 (95% CI, 3.2-15.8) per 100 patient-years using the age-adjusted cutoff values. CONCLUSION:
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Authors | Tobias Tritschler, Andreas Limacher, Marie Méan, Nicolas Rodondi, Drahomir Aujesky |
Journal | The American journal of medicine
(Am J Med)
Vol. 130
Issue 10
Pg. 1221-1224
(10 2017)
ISSN: 1555-7162 [Electronic] United States |
PMID | 28522384
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticoagulants
- Fibrin Fibrinogen Degradation Products
- fibrin fragment D
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Topics |
- Aged
- Aged, 80 and over
- Anticoagulants
(therapeutic use)
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Humans
- Male
- Predictive Value of Tests
- Prospective Studies
- ROC Curve
- Recurrence
- Venous Thromboembolism
(blood, diagnosis, prevention & control)
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