Emerging Evidence on Neutrophil Motility Supporting Its Usefulness to Define Vitamin C Intake Requirements.

Abstract

Establishing intake recommendations for vitamin C remains a challenge, as no suitable functional parameter has yet been agreed upon. In this report, we review the emerging evidence on neutrophil motility as a possible marker of vitamin C requirements and put the results in perspective with other approaches. A recent in vitro study showed that adequate levels of vitamin C were needed for this function to work optimally when measured as chemotaxis and chemokinesis. In a human study, neutrophil motility was optimal at intakes ≥250 mg/day. Interestingly, a Cochrane review showed a significant reduction in the duration of episodes of common cold with regular vitamin C intakes in a similar range. Additionally, it was shown that at a plasma level of 75 µmol/L, which is reached with vitamin C intakes ≥200 mg/day, incidences of cardiovascular disease were lowest. This evidence would suggest that daily intakes of 200 mg vitamin C might be advisable for the general adult population, which can be achieved by means of a diverse diet. However, additional studies are warranted to investigate the usefulness of neutrophil motility as a marker of vitamin C requirements.

• Authors: Volker Elste, Barbara Troesch, Manfred Eggersdorfer, Peter Weber
• Journal: Nutrients (Nutrients) Vol. 9 Issue 5 (May 16 2017) ISSN: 2072-6643 [Electronic] Switzerland
• PMID: 28509882 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Ascorbic Acid

Topics

• Ascorbic Acid (administration & dosage, blood, pharmacology)
• Biomarkers
• Cell Movement (physiology)
• Humans
• Nutritional Requirements