The preclinical discovery of vosaroxin for the treatment of acute myeloid leukemia.

Abstract

INTRODUCTION:

Acute myeloid leukemia (AML) represents a disease with a very poor outcome and remains an area of significant unmet need necessitating novel therapeutic strategies. Among novel therapeutic agents, vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Areas covered: Herein, the authors provide a comprehensive review of the preclinical development of vosaroxin. This includes coverage of vosaroxin's mechanism of action in addition to its pharmacology and of the main studies reported over the past few years with vosaroxin when used to treat adult AML. Expert opinion: Given that vosaroxin is associated with fewer potential side effects, it may be of benefit to elderly patients with relapsed/refractory AML and to those with additional comorbidities who have previously received an anthracycline and cytarabine combination. Furthermore, vosaroxin also was seen to be active in multidrug-resistant preclinical models. However, further studies have to be performed to better evaluate its place in the armamentarium against AML.

• Authors: Etienne Paubelle, Florence Zylbersztejn, Xavier Thomas
• Journal: Expert opinion on drug discovery (Expert Opin Drug Discov) Vol. 12 Issue 7 Pg. 747-753 (07 2017) ISSN: 1746-045X [Electronic] England
• PMID: 28504025 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Naphthyridines
• Thiazoles
• Topoisomerase Inhibitors
• vosaroxin

Topics

• Adult
• Aged
• Animals
• Antineoplastic Agents (adverse effects, pharmacology, therapeutic use)
• Apoptosis (drug effects)
• DNA Breaks, Double-Stranded (drug effects)
• Drug Evaluation, Preclinical (methods)
• Drug Resistance, Multiple
• Drug Resistance, Neoplasm
• Humans
• Leukemia, Myeloid, Acute (drug therapy, pathology)
• Naphthyridines (adverse effects, pharmacology, therapeutic use)
• Thiazoles (adverse effects, pharmacology, therapeutic use)
• Topoisomerase Inhibitors (adverse effects, pharmacology, therapeutic use)