Abstract | AIM: Atherosclerotic lesions in the carotid arteries lead to a broad range of cerebrovascular disorders such as vascular dementia and ischaemic stroke. Recent studies have verified the beneficial role of atorvastatin (AV) in atherosclerosis. Despite a large body of studies, the mechanisms underlying this effect have not been completely explained. In this study, several experiments were performed on atherosclerotic rat models to investigate the anti-inflammatory and anti-apoptotic effect of AV in the carotid artery. METHODS: RESULTS: After eight weeks of feeding with a high- cholesterol diet, an elevated level of oxLDL was observed in the plasma in the HD group compared with the ND group [214.42 ± 17.46 vs 69.13 ± 9.92 mg/dl (5.55 ± 0.45 vs 1.78 ± 0.26 mmol/l); p < 0.01]. AV administration significantly reduced oxLDL levels in the HD + AV compared to the HD group [126.52 ± 9.46 vs 214.42 ± 17.46 mg/dl (3.28 ± 0.25 vs 5.55 ± 0.45 mmol/l); p < 0.01]. Results also showed that compared with the HC group, the HC + AV group had lower levels of p38 phosphorylation (p < 0.05) and higher levels of Bcl-2 expression (p < 0.05). Lower levels of cleaved caspase-3 were observed in the HC + AV group in comparison with the HC group (p < 0.05). CONCLUSIONS: The resultant data suggest that the anti-apoptotic effect of AV could be partially mediated by the pro-inflammatory protein p38 MAPK and the anti-apoptotic protein Bcl-2 in the rat carotid artery. Atorvastatin can therefore be considered a target drug in the prevention or development of atherosclerotic events.
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Authors | Roshanak Bayatmakoo, Nadereh Rashtchizadeh, Parichehreh Yaghmaei, Mehdi Farhoudi, Pouran Karimi |
Journal | Cardiovascular journal of Africa
(Cardiovasc J Afr)
2017 Sep/Oct 23
Vol. 28
Issue 5
Pg. 298-303
ISSN: 1680-0745 [Electronic] South Africa |
PMID | 28498386
(Publication Type: Journal Article)
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Chemical References |
- Anticholesteremic Agents
- Cholesterol
- Atorvastatin
- p38 Mitogen-Activated Protein Kinases
- Caspase 3
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Topics |
- Animals
- Anticholesteremic Agents
(pharmacology)
- Atorvastatin
(pharmacology)
- Carotid Arteries
(drug effects)
- Caspase 3
(drug effects)
- Cholesterol
(blood)
- Down-Regulation
- Genes, bcl-2
(drug effects)
- Male
- Rats, Wistar
- Up-Regulation
- p38 Mitogen-Activated Protein Kinases
(drug effects)
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