Thromboembolic and bleeding risks in patients undergoing atrial fibrillation ablation: oral anticoagulation perspectives.

Abstract

INTRODUCTION:

Atrial fibrillation (AF) is a cause of significant morbidity and mortality. Catheter ablation for AF (CAAF) has emerged as an effective treatment option of rhythm control for patients with symptomatic AF. However, the risk of thromboembolism and bleeding in the periprocedural period represent a worrisome complication of this therapy. The reported incidence of thromboembolic and bleeding events associated with CAAF varies from 0.9% to 5% depending on the CAAF strategy and the anticoagulation regimen used in the periprocedural period. Areas covered: The different anticoagulation regimens used prior to, during, and after CAAF to minimize the risk of thromboembolic and bleeding events are reviewed. The use of uninterrupted oral anticoagulation and appropriate heparin dosing to achieve safe activated clotting time levels are also detailed. A comprehensive approach with assessment of individual risk for thromboembolic and bleeding complications, and understanding the pharmacokinetics of the anticoagulant agents available is also reviewed. Expert opinion: The key advances done in the periprocedural anticoagulation field include the use of uninterrupted anticoagulation strategies in patients undergoing AF ablation and efforts to simplify the selection of patients who need LAA thrombus screening prior to ablation.

• Authors: David F Briceño, Nidhi Madan, Jorge Romero, Alejandra Londoño, Pedro A Villablanca, Andrea Natale, Luigi Di Biase
• Journal: Expert opinion on drug safety (Expert Opin Drug Saf) Vol. 16 Issue 7 Pg. 769-777 (Jul 2017) ISSN: 1744-764X [Electronic] England
• PMID: 28475380 (Publication Type: Journal Article, Review)

Chemical References

• Anticoagulants
• Heparin

Topics

• Anticoagulants (administration & dosage, adverse effects, pharmacokinetics)
• Atrial Fibrillation (complications, therapy)
• Catheter Ablation (adverse effects, methods)
• Dose-Response Relationship, Drug
• Hemorrhage (epidemiology, etiology)
• Heparin (administration & dosage, adverse effects)
• Humans
• Incidence
• Patient Selection
• Thromboembolism (epidemiology, etiology, prevention & control)