Abstract | BACKGROUND: METHODS: Consecutive patients with a multi-disciplinary team diagnosis of CHP (n = 116) had pulmonary function tests (FEV1, FVC, DLco, Kco, and a composite physiologic index [ CPI]) and CT variables predictive of mortality evaluated by analysing visual and computer-based (CALIPER) parenchymal features: total interstitial lung disease (ILD) extent, honeycombing, reticular pattern, ground glass opacities, pulmonary vessel volume (PVV), emphysema, and traction bronchiectasis. Mean survival was compared between both CHP and IPF patients (n = 185). RESULTS: In CHP, visual/CALIPER measures of reticular pattern, honeycombing, visual traction bronchiectasis, and CALIPER ILD extent were predictive of mortality (p < 0 · 05) on univariate analysis. PVV was strongly predictive of mortality on univariate (p < 0 · 0001) and multivariate analysis independent of age, gender and disease severity (represented by the CPI [p < 0 · 01]). CHP patients with a PVV threshold >6 · 5% of the lung had a mean survival (35 · 3 ± 6 · 1 months; n = 20/116 [17%]) and rate of disease progression that closely matched IPF patients (38 · 4 ± 2 · 2 months; n = 185). CONCLUSIONS: Pulmonary vessel volume can identify CHP patients at risk of aggressive disease and a poor IPF-like prognosis.
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Authors | Joseph Jacob, Brian J Bartholmai, Ryoko Egashira, Anne Laure Brun, Srinivasan Rajagopalan, Ronald Karwoski, Maria Kokosi, David M Hansell, Athol U Wells |
Journal | BMC pulmonary medicine
(BMC Pulm Med)
Vol. 17
Issue 1
Pg. 81
(May 04 2017)
ISSN: 1471-2466 [Electronic] England |
PMID | 28472939
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Alveolitis, Extrinsic Allergic
(diagnostic imaging, mortality)
- Blood Volume
- Chronic Disease
- Disease Progression
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
(mortality)
- Lung
(blood supply, diagnostic imaging, physiopathology)
- Male
- Middle Aged
- Multivariate Analysis
- Predictive Value of Tests
- Pulmonary Alveoli
(blood supply, diagnostic imaging)
- Pulmonary Circulation
- Respiratory Function Tests
- Severity of Illness Index
- Survival Analysis
- Tomography, X-Ray Computed
- United Kingdom
(epidemiology)
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