Enhanced Fluorescence Imaging and Photodynamic Cancer Therapy Using Hollow Mesoporous Nanocontainers.

Abstract

Here we show that "off-on" type of photodynamic therapy agents could be developed using hollow mesoporous silica nanoparticles (HMSNPs), which can be used not only for enhancing delivery of photosensitizers to cancer cells but also for enabling switchable optical properties of the photosensitizers. Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. In vitro cell studies showed that this HMSNP-based "off-on" agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers.

• Authors: Suk Ho Hong, Hyunjin Kim, Yongdoo Choi
• Journal: Chemistry, an Asian journal (Chem Asian J) Vol. 12 Issue 14 Pg. 1700-1703 (Jul 18 2017) ISSN: 1861-471X [Electronic] Germany
• PMID: 28463441 (Publication Type: Journal Article)
• Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Drug Carriers
• Photosensitizing Agents
• Porphyrins
• Silicon Dioxide
• Talaporfin

Topics

• Cell Line, Tumor
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Drug Carriers (chemistry)
• Humans
• Microscopy, Confocal
• Nanoparticles (chemistry)
• Optical Imaging
• Particle Size
• Photochemotherapy
• Photosensitizing Agents (chemistry, pharmacology)
• Porosity
• Porphyrins (chemistry, pharmacology)
• Silicon Dioxide (chemical synthesis, chemistry, pharmacology)
• Structure-Activity Relationship
• Surface Properties