Administration of Aacetylsalicylic
acid in children with
viral infections (influence B,
chickenpox) can be related with development of
Reye syndrome - severe
encephalopathy and
liver insufficiency with mortality in 50% of cases. During
Reye syndrome most important is deficiency of
carnitine and hepatocyte damage. Decreased amount of
carnitine impairs the energy function of mitochondria and gluconeogenesis as well as production of
urea. As a result develops
toxic encephalopathy and
liver insufficiency. The goal of the research was assessment of efficacy of
L-Carnitine,
Corvitin and their combination on functional state of liver in experimental model of
Reye Syndrome in rats. The study was performed on mature white male Wistar rates with body mass 150-180g. 50 rats were randomly divided into 5 groups (10 rats in each group). The model of
Reye syndrome was induced in accordance with A.Vengersky's method. Intraperitoneal administration of
4-pentenoic acid was performed once daily during seven days, the used dosage was 20mg/kg. The treatment of
toxic hepatitis was carried with intraperitoneal administration of
L-Carnitine 300mg/kg, Corvitine 100mg/kg and concurrent administration of these drugs. Monotherapy with
Corvitin and L-Carnitin successfully improved liver function and equally decreased indicators of hepatocyte's cytolyses and increased levels of
glucose and
urea. The markers of
cholestasis was slightly more improved during use of
L-Carnitine. Simultaneous use of both drugs was effective in rats with
Reye syndrome, indicators of liver damage normalized and herewith, no mortality outcome was observed. The most pronounced hepatoprotective effect of concurrent administration of
L-Carnitine and
Corvitin may be due to synergic action of these drugs and such regime can be recommended for correction of liver function during
Reye syndrome.