Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition.

Abstract

To inhibit binding of the influenza A virus to the host cell glycocalyx, we generate multivalent peptide-polymer nanoparticles binding with nanomolar affinity to the virus via its spike protein hemagglutinin. The chosen dendritic polyglycerol scaffolds are highly biocompatible and well suited for a multivalent presentation. We could demonstrate in vitro that by increasing the size of the polymer scaffold and adjusting the peptide density, viral infection is drastically reduced. Such a peptide-polymer conjugate qualified also in an in vivo infection scenario. With this study we introduce the first non-carbohydrate-based, covalently linked, multivalent virus inhibitor in the nano- to picomolar range by ensuring low peptide-ligand density on a larger dendritic scaffold.

• Authors: Daniel Lauster, Maria Glanz, Markus Bardua, Kai Ludwig, Markus Hellmund, Ute Hoffmann, Alf Hamann, Christoph Böttcher, Rainer Haag, Christian P R Hackenberger, Andreas Herrmann
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 56 Issue 21 Pg. 5931-5936 (05 15 2017) ISSN: 1521-3773 [Electronic] Germany
• PMID: 28444849 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antiviral Agents
• Peptides

Topics

• Antiviral Agents (chemistry, pharmacology)
• Erythrocytes (drug effects)
• Humans
• Influenza, Human (drug therapy)
• Molecular Structure
• Nanoparticles (chemistry)
• Peptides (chemistry)