Abstract | BACKGROUND: MATERIAL AND METHODS: Eighteen children and 21 adults, with clinical history of immediate reactions to AMX or AMX-C, were referred to Anna Meyer Children's Hospital and San Giovanni di Dio Hospital, respectively. They underwent in vivo tests (skin prick test and intradermal test). Moreover, BAT with AMX or AMX-C was performed within 6 months from the reaction. RESULTS: In the pediatric group, the concordance between the skin tests (ST) and BAT results was 83.3%. Upon comparing the symptom grades and ST results to the BAT results, we found that the reaction severity and ST positivity did not correlate with BAT results in children. In the adult group, the concordance between the ST and BAT results was 61.9%. Upon comparing patients with severe reactions and patients with mild reactions in terms of BAT results, we found a BAT sensitivity of 38.5% and a specificity of 100%. When comparing the symptom grades to the BAT results, we found that no patients with mild symptoms had a positive BAT result, whereas 38.5% of patients with severe symptoms had a positive BAT result. CONCLUSIONS:
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Authors | Simona Barni, Francesca Mori, Claudia Valleriani, Giusi Mangone, Sergio Testi, Francesca Saretta, Lucrezia Sarti, Neri Pucci, Maurizio de Martino, Chiara Azzari, Elio Novembre |
Journal | Italian journal of pediatrics
(Ital J Pediatr)
Vol. 43
Issue 1
Pg. 42
(Apr 21 2017)
ISSN: 1824-7288 [Electronic] England |
PMID | 28431585
(Publication Type: Comparative Study, Letter)
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Chemical References |
- Amoxicillin-Potassium Clavulanate Combination
- Amoxicillin
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Topics |
- Adolescent
- Adult
- Age Factors
- Amoxicillin
(administration & dosage, immunology)
- Amoxicillin-Potassium Clavulanate Combination
(administration & dosage, immunology)
- Basophils
(drug effects, immunology)
- Child
- Child, Preschool
- Cohort Studies
- Databases, Factual
- Drug Hypersensitivity
(diagnosis, immunology)
- Female
- Humans
- Hypersensitivity, Immediate
(diagnosis, immunology)
- Immunologic Tests
(methods)
- Male
- Retrospective Studies
- Risk Assessment
- Sensitivity and Specificity
- Skin Tests
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