Abstract | BACKGROUND: METHODS: We randomly allocated Dahl salt-sensitive rats fed a high- salt diet from 6 weeks of age into CBD (n = 31) and sham-operation ( SHAM; n = 50) groups, and conducted CBD or SHAM at 7 weeks of age. We examined the time course of 24-hour urinary norepinephrine (uNE) excretion, blood pressure (BP) and the percent fractional shortening assessed by echocardiography, and estimated the pressure-natriuresis relationship at 14 weeks of age. Finally, we assessed hemodynamics, histological findings, and survival at 16 weeks of age. RESULTS: Compared to SHAM, CBD significantly reduced 24-hour uNE at 12, 14, and 16 weeks of age, shifted the pressure-natriuresis relationship leftward without changing its slope, and attenuated the increase in BP. CBD preserved percent fractional shortening (34.2 ± 1.2 vs. 29.1 ± 1.3%, P < 0.01) and lowered left ventricular end-diastolic pressure (5.0 ± 0.9 vs. 9.0 ± 1.4 mm Hg, P < 0.05). Furthermore, CBD significantly attenuated myocardial hypertrophy (P < 0.01) and fibrosis (P < 0.01). Consequently, CBD markedly improved survival (relative risk reduction: 64.8%). CONCLUSIONS: CBD attenuated the progression of hypertension and worsening of heart failure possibly through sympathoinhibition, and markedly improved survival in a rat model of hypertensive heart failure.
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Authors | Kana Fujii, Keita Saku, Takuya Kishi, Yasuhiro Oga, Takeshi Tohyama, Takuya Nishikawa, Takafumi Sakamoto, Masataka Ikeda, Tomomi Ide, Hiroyuki Tsutsui, Kenji Sunagawa |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 30
Issue 8
Pg. 791-798
(Aug 01 2017)
ISSN: 1941-7225 [Electronic] United States |
PMID | 28430843
(Publication Type: Journal Article)
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Copyright | © American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: [email protected] |
Chemical References |
- Sodium, Dietary
- Norepinephrine
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Topics |
- Animals
- Blood Pressure
- Carotid Body
(surgery)
- Disease Progression
- Echocardiography
- Heart Failure
(diagnostic imaging, etiology, surgery)
- Hypertension
(complications)
- Natriuresis
- Norepinephrine
(urine)
- Rats
- Rats, Inbred Dahl
- Sodium, Dietary
- Survival Analysis
- Sympathectomy
(methods)
- Ventricular Function, Left
- Ventricular Remodeling
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