Abstract |
Circular RNAs ( circRNAs) are a novel class of non-coding RNA which have recently shown huge capabilities in the regulation of gene expression at the post-transcriptional level. Growing evidence has indicated that circRNAs could serve as competing endogenous RNAs (ceRNAs) to bind with microRNAs ( miRNAs) and to inhibit the activity and function of the targeted miRNAs. Here, we demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion. Moreover, circ-0016347 was identified as a sponge of miR-214 that upregulated the expression of caspase-1, which is the functional target of miR-214. Our study provides novel insight into the regulatory mechanism of circ-0016347 and its downstream targets in proliferation, invasion and metastasis of osteosarcoma cells, which will facilitate further development in the therapy of osteosarcoma.
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Authors | Hao Jin, Xin Jin, Hong Zhang, Wenbo Wang |
Journal | Oncotarget
(Oncotarget)
Vol. 8
Issue 15
Pg. 25571-25581
(Apr 11 2017)
ISSN: 1949-2553 [Electronic] United States |
PMID | 28424426
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- MIRN214 microRNA, human
- MicroRNAs
- RNA, Circular
- RNA
- Caspase 1
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Topics |
- Animals
- Biomarkers, Tumor
- Bone Neoplasms
(genetics, metabolism, pathology)
- Caspase 1
(genetics, metabolism)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
- Disease Models, Animal
- Epistasis, Genetic
- Gene Expression Regulation, Neoplastic
- Heterografts
- Humans
- Male
- Mice
- MicroRNAs
(genetics)
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Osteosarcoma
(genetics, metabolism, pathology)
- RNA
- RNA Interference
- RNA, Circular
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