Abstract | BACKGROUND:
Angiotensin II receptor type 1-mediated activation of the α-subunit of the heterotrimeric Gq protein evokes increased vasoconstriction and may promote hypertrophy-induced myocardial damage. The authors recently identified a TT(-695/-694)GC polymorphism in the human Gq promoter, the GC allele being associated with an increased prevalence of cardiac hypertrophy. In this article, the authors tested whether the TT(-695/-694)GC polymorphism is associated with differences in (1) myocardial Gq protein expression, (2) vascular reactivity, and (3) myocardial damage after coronary artery bypass grafting. METHODS: RESULTS: Myocardial Gq expression was greater in GC/GC genotypes (GC/GC vs. TT/TT: 1.27-fold change; P = 0.006). Skin perfusion after intradermal angiotensin II injection decreased only in GC/GC genotypes (P = 0.0002). Saphenous vein rings exposed to increasing angiotensin II concentrations showed an almost doubled maximum contraction in GC/GC compared with individuals with the TT/TT genotype (P = 0.022). In patients undergoing coronary artery bypass grafting, baseline cardiac ejection fraction was different (GC/GC: 55 ± 13%; GC/TT: 54 ± 14%; TT/TT: 48 ± 15%; P = 0.037) and postoperative peak cardiac troponin I was greater in patients with the GC/GC (11.5 ± 13.8 ng/ml) than in patients with the GC/TT (9.2 ± 9.2 ng/ml) or patients with the TT/TT genotype (6.6 ± 4.8 ng/ml, P = 0.015). CONCLUSIONS:
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Authors | Ulrich H Frey, Stefanie Klenke, Anna Mitchell, Tim Knüfermann, Heinz Jakob, Matthias Thielmann, Winfried Siffert, Jürgen Peters |
Journal | Anesthesiology
(Anesthesiology)
Vol. 127
Issue 1
Pg. 70-77
(07 2017)
ISSN: 1528-1175 [Electronic] United States |
PMID | 28422819
(Publication Type: Journal Article)
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Chemical References |
- GNAQ protein, human
- Troponin I
- GTP-Binding Protein alpha Subunits, Gq-G11
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Topics |
- Aged
- Coronary Artery Bypass
- Female
- GTP-Binding Protein alpha Subunits, Gq-G11
(genetics, metabolism)
- Heart
(physiopathology)
- Humans
- Male
- Myocardium
(metabolism)
- Polymorphism, Genetic
(genetics)
- Postoperative Complications
(genetics, metabolism, physiopathology)
- Troponin I
(blood)
- Vasoconstriction
(physiology)
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