Promising silicones modified with cationic biocides for the development of antimicrobial medical devices.

Abstract

We have tested silicones containing 2% or 5% of the cationic biocides polyhexamethylene guanidine dodecylbenzenesulfonate (PHMG-DBS), 1-octyl-3-methylimidazolium tetrafluoroborate (OMIM-BF4) or 1-dodecyl-3-methylimidazolium tetrafluoroborate (DMIM-BF4) against the major relevant bacterial and yeast species in health care-associated infections (HCAI). Study conducted according to the international standard ISO 22196 revealed that silicones containing 2% or 5% DMIM-BF4 or 5% PHMG-DBS presented the highest antimicrobial activity, leading to a logarithmic growth reduction of 3.03 to 6.46 and 3.65 to 4.85 depending on the bacterial or fungal species. Heat-pretreated silicones containing 2% DMIM-BF4 kept a high activity, with at least a 3-log reduction in bacterial growth, except against P. aeruginosa where there was only a 1.1-log reduction. After 33days, the release ratio of cationic biocide from silicone films containing 5% of DMIM-BF4 was found to be 5.6% in pure water and 1.9% in physiological saline solution, respectively. No leaching of PHMG-DBS polymeric biocide was detected under the same conditions. These results demonstrate unambiguously that silicones containing 2% DMIM-BF4 or 5% PHMG-DBS present high antimicrobial activity, as well as high leaching resistance and therefore may be good candidates for the development of safer medical devices.

• Authors: Sarah Ghamrawi, Jean-Philippe Bouchara, Oksana Tarasyuk, Sergiy Rogalsky, Lyudmila Lyoshina, Olga Bulko, Jean-François Bardeau
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 75 Pg. 969-979 (Jun 01 2017) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 28415553 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Infective Agents
• Disinfectants
• Silicones

Topics

• Acinetobacter baumannii (drug effects)
• Anti-Infective Agents (chemistry, pharmacology)
• Disinfectants (chemistry)
• Enterobacter cloacae (drug effects)
• Equipment and Supplies
• Pseudomonas aeruginosa (drug effects)
• Silicones (chemistry)
• Staphylococcus aureus (drug effects)
• Staphylococcus epidermidis (drug effects)