Abstract |
Maternal vitamin A intake varies but its impact on offspring metabolic health is unknown. Here we found that maternal vitamin A or retinoic acid (RA) administration expanded PDGFRα+ adipose progenitor population in progeny, accompanied by increased blood vessel density and enhanced brown-like (beige) phenotype in adipose tissue, protecting offspring from obesity. Blockage of retinoic acid signaling by either BMS493 or negative RA receptor (RARαDN) over-expression abolished the increase in blood vessel density, adipose progenitor population, and beige adipogenesis stimulated by RA. Furthermore, RA-induced beige adipogenesis was blocked following vascular endothelial growth factor receptor (VEGFR) 2 knock out in PDGFRα+ cells, suggesting its mediatory role. Our data reveal an intrinsic link between maternal retinoid level and offspring health via promoting beige adipogenesis. Thus, enhancing maternal retinoids is an amiable therapeutic strategy to prevent obesity in offspring, especially for those born to obese mothers which account for one third of all pregnancies.
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Authors | Bo Wang, Xing Fu, Xingwei Liang, Zhixiu Wang, Qiyuan Yang, Tiande Zou, Wei Nie, Junxing Zhao, Pengfei Gao, Mei-Jun Zhu, Jeanene M de Avila, Joseph Maricelli, Buel D Rodgers, Min Du |
Journal | EBioMedicine
(EBioMedicine)
Vol. 18
Pg. 288-299
(Apr 2017)
ISSN: 2352-3964 [Electronic] Netherlands |
PMID | 28408241
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Vascular Endothelial Growth Factor A
- Vitamin A
- Tretinoin
- Receptor, Platelet-Derived Growth Factor alpha
- Retinaldehyde
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Topics |
- Adipogenesis
(drug effects)
- Adipose Tissue, Beige
(cytology, metabolism, pathology)
- Animals
- Body Temperature
- Cells, Cultured
- Chromatography, High Pressure Liquid
- Diet, High-Fat
- Dietary Supplements
- Female
- Glucose Tolerance Test
- Male
- Mice
- Mice, Inbred C57BL
- Obesity
(pathology, prevention & control)
- Oxygen Consumption
(drug effects)
- Pregnancy
- Receptor, Platelet-Derived Growth Factor alpha
(metabolism)
- Retinaldehyde
(blood)
- Signal Transduction
(drug effects)
- Stromal Cells
(cytology, drug effects, metabolism)
- Tretinoin
(blood, pharmacology)
- Vascular Endothelial Growth Factor A
(genetics, metabolism)
- Vitamin A
(blood, pharmacology)
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