Abstract | BACKGROUND:
Salmeterol is a long-acting β2-adrenergic receptor agonist used to treat chronic obstructive pulmonary disease. The authors of the current study previously showed that preincubation of primary microglial-enriched cells with salmeterol could inhibit the inflammatory response induced by Escherichia coli lipopolysaccharide (LPS), a Toll-like receptor (TLR)-4 agonist. In this study, the authors sought to determine if salmeterol had a similar inhibitory effect on the inflammatory response of the murine macrophage cell line RAW264.7 and human monocyte THP-1 to LPS from Porphyromonas gingivalis (PgLPS), an oral microbe implicated in the pathogenesis of periodontal disease. METHODS: RESULTS: CONCLUSION:
Salmeterol can significantly inhibit activation of macrophage-mediated inflammation by PgLPS, suggesting that use of salmeterol may be an effective treatment in inhibiting or lessening the inflammatory response mediated through TLR pathway activation.
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Authors | Monika Sharma, Lindsay Patterson, Elisha Chapman, Patrick M Flood |
Journal | Journal of periodontology
(J Periodontol)
Vol. 88
Issue 7
Pg. 681-692
(07 2017)
ISSN: 1943-3670 [Electronic] United States |
PMID | 28398147
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-2 Receptor Agonists
- Lipopolysaccharides
- NF-kappa B
- NF-KappaB Inhibitor alpha
- Salmeterol Xinafoate
- p38 Mitogen-Activated Protein Kinases
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Topics |
- Adrenergic beta-2 Receptor Agonists
(pharmacology, therapeutic use)
- Animals
- Down-Regulation
- Enzyme-Linked Immunosorbent Assay
- Humans
- Inflammation
(drug therapy)
- Lipopolysaccharides
(pharmacology)
- Macrophage Activation
(drug effects)
- Mice
- NF-KappaB Inhibitor alpha
(metabolism)
- NF-kappa B
(metabolism)
- Phosphorylation
- Porphyromonas gingivalis
- RAW 264.7 Cells
- Salmeterol Xinafoate
(pharmacology, therapeutic use)
- THP-1 Cells
- p38 Mitogen-Activated Protein Kinases
(metabolism)
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